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KMID : 0380020120270060375
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Korean Journal of Biotechnology and Bioengineering
2012 Volume.27 No. 6 p.375 ~ p.380
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The Evaluation of Antithrombotic and Fibrinolytic Activities of Nattokinase from Bacillus subtilis Natto
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Lee Da-Lyung
Hong Sung-Yu
Jang Yang-Su
Jang Hyung-Wook
Maeng Chang-Jae
Yoo Chul-Bae
Baek Dae-Heoun
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Abstract
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We previously reported that Ultra nattokinaseⓡ showed high fibrinolytic activity and revealed antithrombotic effect in rat blood plasma based on its ability to suppress collagen-induced platelet aggregation. This research was carried out to verify the clot lysing activity and blood flow enhancing effects of Ultra nattokinaseⓡ via monitoring and comparing the antithrombotic effects in rat artery between oral administration of Ultra nattokinaseⓡ and maltodextrin. SD rats were fed with 1.11 mg/kg of Ultra nattokinaseⓡ for 4 weeks. The effect on arterial thrombosis was then evaluated using an antithrombotic model after induction by FeCl3. Detected fibrinolytic activity was proportional to the content of Ultra nattokinaseⓡ and statistical extents of the antithrombotic activity was enhanced strongly twice rather than control group. The PT and the aPTT, however, showed only a small difference between two groups. The results suggest that Ultra nattokinaseⓡ can effectively treat thromboembolism and enhance blood flow, and that Ultra nattokinaseⓡ can also prevent venous occlusion by aiding clot lysis.
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KEYWORD
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Bacillus subtilis Natto, Ultra nattokinase(R), Antithrombotic effect, Fibrinolytic effect, Platelet aggregation
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